Phase T1 translational research involves
work that develops concepts and discoveries from basic research through early phase clinical trials in humans
. … Phase T1 translational research typically is described as “bench to bedside.”
What are 3 types of translational research?
Types of studies/activities – Dissemination research; implementation research;
diffusion research
, Phase IV clinical trials.
What does T1 mean in research?
T1 involves
processes that bring ideas from basic research through early testing in humans
. T2 involves the establishment of effectiveness in humans and clinical guidelines. T3 primarily focuses on implementation and dissemination research while T4 focuses on outcomes and effectiveness in populations.
What is T2 in translational research?
For the purposes of this FOA, T2 translational research on aging is defined as
research to gather information needed to develop or evaluate methods of translating results from clinical studies into everyday clinical practice and health decision making
(e.g., adapting an efficacious intervention for application in …
What is T0 in translational research?
T
0
is characterized
by the identification of opportunities and approaches to health problems
. T
1
seeks to move basic discovery into a candidate health application. T
2
assesses the value of application for health practice leading to the development of evidence-based guidelines.
What is an example of translational research?
One prime example of translational research in human disease is
the study of cancer therapy
. Extensive cooperation between basic researchers, clinicians, and industry has generated numerous new targeted compounds with enhanced efficacy and decreased toxicity.
What is T1 T4?
T0, T1 and T2 are
hormone precursors and byproducts of thyroid hormone synthesis
. They do not act on the thyroid hormone receptor and appear to be totally inert. T4 is inert too, but conversion to T3 (in the liver, kidneys, brain, and other organs) activates it, in a highly regulated way.
Why do we need translational research?
The goal of translational research is
to give practitioners the latest information from basic-research labs in usable form
. The idea is to produce better medications, improve diagnostic and treatment strategies, and enhance health through the application of information from basic science research.
What is the difference between applied and translational research?
What is the difference between applied and translational research?
Translational research is broader than the traditional term “applied research
.” Applied research is any research that may possibly be useful for enhancing health or well-being.
Is evidence-based practice the same as translational research?
Evidence-based practice and translation science are
not interchangeable terms
; EBP is the application of evidence in practice (the doing of EBP), whereas translation science is the study of implementation interventions, factors, and contextual variables that affect knowledge uptake and use in practices and communities.
What are the stages of translational research?
- T
1
(Phase I and II Clinical Trials) – Integrate a basic scientific discovery into a candidate health-care application. - T
2
(Phase III Clinical Trials) – Assess the value of the application for health-care practice and develop evidence-based guidelines for using the application.
How is data collected in translational research?
Translational research involves many scientists and clinicians compiling multiple data types and sources. These may include
deidentified patient data, whole genome or exome sequences
, specific tumor sequences, specimen records from patient blood draws, biopsies, and more.
What is T3 translational research?
T3 research
explores ways of applying recommendations or guidelines in general practice
. T3 research yields knowledge about how interventions work in real-world settings. Approaches include: Phase IV Clinical Trials: Studies conducted after the intervention has been marketed.
Who funds translational research?
In the United States, translational research is funded, in large part, by
Clinical and Translational Science Awards (CTSAs)
, a program that is part of the Division of Clinical Innovation at the NIH National Center for Advancing Translational Sciences (NCATS).
What is meant by translational?
The adjective “translational” refers to
the “translation”
(the term derives from the Latin for “carrying over”) of basic scientific findings in a laboratory setting into potential treatments for disease.
What is a translational research study?
What is it? Translational Research
takes scientific discoveries made in the laboratory
, in the clinic or out in the field and transforms them into new treatments and approaches to medical care that improve the health of the population.*
