Results. The Moghul population shows the highest allele frequency of sickle cell gene, i.e.,
16.96%
while Naga shows the least, i.e., 8.6%. Females show a higher allele frequency of the sickle cell gene, i.e., 29.83% than males who show a frequency of 21.99%.
What is the frequency of sickle cell disease?
In the United States
It is estimated that: SCD affects
approximately 100,000 Americans
. SCD occurs among about 1 out of every 365 Black or African-American births. SCD occurs among about 1 out of every 16,300 Hispanic-American births.
What is the frequency of the HbS allele?
Our HbS map (Fig. 1b) showed an HbS allele frequency of
>0.5%
to be present throughout most of the African continent, the Middle East and India and in localized areas in Mediterranean countries. The maximum predicted value of HbS allele frequency was 18.18% in northern Angola.
Where is the sickle cell allele most frequent?
The allele for sickle-cell disease is most common in
people of African ancestry
. The reason for this probably has to do with the relationship between the sickle-cell trait and malaria. Malaria, a disease common in parts of Africa, affects red blood cells.
How many alleles is sickle cell caused by?
The sickle cell anemia trait is found on a recessive allele of the hemoglobin gene. This means that you must have
two copies of the recessive allele
— one from your mother and one from your father — to have the condition. People who have one dominant and one recessive copy of the allele won't have sickle cell anemia.
What gender is most affected by sickle cell anemia?
Although no particular gender predilection has been shown in most series, analysis of the data from the US Renal Data System demonstrated marked
male
predominance of sickle cell nephropathy in affected patients.
Can a white person have sickle cell?
Answer.
Yes, they can
. Sickle cell disease can affect people of ANY race or ethnicity. Sickle cell disease, an inherited disorder of the red blood cells, is more common in African Americans in the U.S. compared to other ethnicities—occurring in approximately 1 in 365 African Americans.
What blood type carries sickle cell?
Like most genes, individuals inherit one from each parent. Examples: If one parent has sickle cell anemia (
SS
) and the other parent has normal (AA) blood, all of the children will have sickle cell trait.
Is HbS a gene?
HbS is
a change to the normal Hb gene
. An abnormal HbS gene causes red blood cells to become sickle shaped, which can limit the amount of oxygen the red blood cells can carry through the body. The hemoglobin gene inherited from each birth parent is very important because it can cause: Sickle cell disease.
What are the normal and sickle cell alleles called?
Genetics. Normally, a person inherits two copies of the gene that produces beta-globin, a protein needed to produce normal hemoglobin (hemoglobin A, genotype AA). A person with sickle cell trait inherits
one normal allele and one abnormal allele encoding hemoglobin S
(hemoglobin genotype AS).
Why do only black people get sickle cell?
People with one sickle cell gene carry SCT, which typically does not cause severe disease. However, African Americans
are at a much higher risk of experiencing SCD
. Researchers believe this could be because SCD evolved in human populations living where malaria is common, to help protect against the disease.
What was Dr Allison's initial observations?
What were Dr. Allison's initial questions when he went to East Africa in 1949?
distribution of the ABO blood groups and other inherited characteristics, including the sickle cell allele, in East African tribes
.
Who does sickle cell affect the most?
In the United States, most of the people with SCD are
African Americans
: About 1 in 13 African American babies is born with sickle cell trait. About 1 in every 365 black children is born with sickle cell disease.
Can AA and SS marry?
AC is rare whereas AS and AC are abnormal. Compatible genotypes for marriage are: AA marries an AA. … And definitely,
SS and SS must not marry since
there's absolutely no chance of escaping having a child with the sickle cell disease.
Is sickle cell curable?
Stem cell or bone marrow transplants are the only cure for sickle cell disease
, but they're not done very often because of the significant risks involved. Stem cells are special cells produced by bone marrow, a spongy tissue found in the centre of some bones.
Is Sickle cell trait and Covid 19?
Sickle cell disease (SCD) and sickle cell trait (SCT) are genetic conditions that occur predominantly among Black individuals. It is
unknown
if individuals with SCD/SCT are at higher risk of severe COVID-19 illness compared with Black individuals who do not have SCD/SCT.
