| X B X b | Y X B Y X b Y |
|---|
Which genotypes are possible for the parents of a hemophiliac female?
The
X chromosome
from the father with hemophilia will have the hemophilia gene. The girl also gets an X chromosome from her mother. If she gets the normal X chromosome, the girl will be a carrier. If she gets the X chromosome with the hemophilia gene, she will have hemophilia.
What is the genotype of a woman with hemophilia?
| Phenotype Genotype | Normal male XHY | Normal female XHXH | Affected male XhY | Carrier female XhXH |
|---|
Can hemophilia be passed from father to son?
Most people who have hemophilia are born with it.
It almost always is inherited (passed down) from a parent to a child
.
How is hemophilia A passed from parent to child if a mother is a carrier What is the likelihood that she’ll pass that gene on to a son to a daughter?
If the mother is a carrier it’s likely that she may pass down one copy of the X chromosome. There is a
50 percent chance
that she’ll pass down the mutated chromosome to her daughters who will become carriers and a 50 percent chance that she’ll pass down the gene to her sons who will develop the disease.
Can hemophilia be cured?
There is currently no cure for hemophilia
. Effective treatments do exist, but they are expensive and involve lifelong injections several times per week to prevent bleeding.
Why can females only be carriers of hemophilia?
Hemophilia can affect women, too
When a female has hemophilia, both X chromosomes are affected or one is affected and the other is missing or non-functioning. In these females, bleeding symptoms can be similar to males with hemophilia.
When a female has one affected X chromosome
, she is a “carrier” of hemophilia.
Which type of hemophilia is more severe?
Hemophilia A
affects 1 in 5,000 to 10,000 males. Hemophilia B is less common, affecting 1 in 25,000 to 30,000 males. Around 60% to 70% of people with hemophilia A have the severe form of the disorder and about 15% have the moderate form. The rest have mild hemophilia.
Can males pass on hemophilia?
Thus,
males can have a disease like hemophilia if they inherit an affected X chromosome that has a mutation in either the factor VIII or factor IX gene
. Females can also have hemophilia, but this is much rarer.
Can hemophilia skip a generation?
Fact: Due to the genetic inheritance patterns of hemophilia,
the condition can skip a generation
, but it doesn’t always.
Who carries the gene for hemophilia?
Hemophilia is an inherited disease, most commonly affecting males, that is characterized by a deficiency in blood clotting. The responsible gene is located on
the X chromosome
, and since males inherit only one copy of the X chromosome, if that chromosome carries the mutated gene then they will have the disease.
Which parent gives hemophilia to daughter?
A father who has
hemophilia possesses the gene
and passes it on to his daughter because daughters receive two X chromosomes, one from their mother and one from their father. This is why daughters of men with hemophilia are called obligate carriers.
What is the probability of a male offspring being a carrier developing hemophilia?
Most, but not all, mothers who have a son with hemophilia are carriers. A female who is a carrier has a
50 – 50 chance
that each male child will have hemophilia. There is a 50 – 50 chance that each female child will be a carrier (Picture 2).
What is the blood type of the father if the daughter is type O and the mother is type A?
| Inherited Blood type of child | O from the mother B from the father B |
|---|
Why is hemophilia called the Christmas disease?
Hemophilia B occurs when clotting factor IX is either absent or not present in sufficient amounts. Hemophilia B is also known as Christmas disease. It is
named after the first person to be diagnosed with the disorder in 1952, Stephen Christmas
.
Why haemophilia called bleeder’s disease?
Hemophilia is a disorder
in which a person’s blood is not able to clot normally
. In normal blood, proteins called clotting factors work together to form a clot whenever bleeding occurs. The person with hemophilia lacks or doesn’t have enough of a certain clotting factor so the blood can’t make a clot.
