What Is The Mechanism Of Action Of KAYEXALATE?

Mechanism Of Action

KAYEXALATE

increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract

. Binding of potassium reduces the concentration of free potassium in the gastrointestinal lumen, resulting in a reduction of serum potassium levels.

What happens when you take KAYEXALATE?

This medication may cause serious (rarely fatal)

intestinal problems

(such as bleeding, blockage). Get medical help right away if any of these very serious side effects occur: severe constipation, bloating/swelling/pain in the stomach/abdomen, black/bloody stools, vomit that looks like coffee grounds.

How does Kayexalate work in the body?

Kayexalate (sodium polystyrene) is a cation-exchange resin used to treat high levels of potassium in the blood, also called hyperkalemia. Kayexalate works by

helping your body get rid of extra potassium

.

How does KAYEXALATE remove potassium?

KAYEXALATE can be administered either orally or as an enema. Sodium polystyrene sulfonate is not absorbed from the gastrointestinal tract. As the resin passes through the gastrointestinal tract, the resin removes the potassium ions

by exchanging it for sodium ions

.

How does KAYEXALATE treat hyperkalemia?

Kayexalate (Sodium polystyerene sulfonate) is a cation-exchange resin that was approved in 1958 as a treatment for

hyperkalemia by helping to exchange sodium for potassium in the colon and thus excreting potassium from the body

. This drug has been a standard part of treatment of hyperkalemia for decades.

When should I stop taking KAYEXALATE?

1. stomach pain, rectal pain;
2. severe constipation, severe stomach pain, bloating;
3. fever, chills, vomiting;
4. confusion, thinking problems, feeling irritable;

What are the side effects of KAYEXALATE?

• loss of appetite,
• upset stomach,
• nausea,
• vomiting,
• constipation, or.
• diarrhea.

Does Kayexalate give you diarrhea?

KAYEXALATE may cause some degree of gastric irritation. Anorexia, nausea, vomiting, and constipation may occur especially if high doses are given. Also, hypokalemia, hypocalcemia, and significant sodium retention, and their related clinical manifestations, may occur (see WARNINGS).

Occasionally diarrhea develops

.

At what potassium level should Kayexalate be given?

They concluded that a 30-g dose of SPS should be administered to patients with serum potassium levels of

between 5 and 6 mEq/L

, and that a 60-g dose should be given to those with serum potassium levels of greater than 6.0 mEq/L.

What’s a normal potassium level?

Normally, your blood potassium level is

3.6 to 5.2 millimoles per liter (mmol/L)

. A very low potassium level (less than 2.5 mmol/L ) can be life-threatening and requires urgent medical attention.

How can I lower my potassium level?

1. root vegetables, such as beets and beet greens, taro, parsnips, and potatoes, yams, and sweet potatoes (unless they’re boiled)
2. bananas and plantains.
3. spinach.
4. avocado.
5. prunes and prune juice.
6. raisins.
7. dates.
8. sun-dried or pureed tomatoes, or tomato paste.

What is the most common cause of hyperkalemia?

Advanced kidney disease

is a common cause of hyperkalemia. A diet high in potassium. Eating too much food that is high in potassium can also cause hyperkalemia, especially in people with advanced kidney disease. Foods such as cantaloupe, honeydew melon, orange juice, and bananas are high in potassium.

What’s the antidote for potassium?

Sodium bicarbonate, which temporarily shifts potassium into body cells. Albuterol, which raises blood insulin levels and shifts potassium into body cells.

Sodium polystyrene sulfonate

(Kayexalate), which removes potassium through your intestines before it’s absorbed.

What is the antidote for hyperkalemia?

Antagonize any electrocardiographic changes caused by hyperkalemia with

i.v. calcium chloride or gluconate

. Repeat the dose if the changes do not resolve or recur.

Is hyperkalemia curable?

Mild hyperkalemia is usually treated without hospitalization

especially if the patient is otherwise healthy, the ECG is normal, and there are no other associated conditions such as acidosis and worsening kidney function. Emergency treatment is necessary if hyperkalemia is severe and has caused changes in the ECG.

What happens if you have too much potassium in your body?

Having too much potassium in your blood can be dangerous. Potassium affects the way your heart’s muscles work. When you have too much potassium, your heart may beat irregularly, which in the worst cases, can

cause heart attack

. If you think you are having a heart attack, call 911 for emergency help.