Maternal-to-fetal transfer
occurs across the placental barrier, made up of both the syncytiotrophoblast on the maternal side and the endothelial cell layer on the fetal side.
Which of the following agents would most readily cross the placenta?
Induction agents
Thiopental
is the most commonly used induction agent in parturients. It is a highly lipid-soluble weak acid which is 61% unionized at plasma pH and 75% bound to plasma albumin. It rapidly crosses the placenta and is quickly cleared by the neonate after delivery.
Which of the following is the most important factor in determining what crosses the placental barrier?
The primary determining factors of what type of drugs will cross the placental barrier are
molecular weight
, lipid (fat or fat-like) solubility, polarity (molecular charge), protein binding, and receptor mediation.
Which of the following drugs Cross blood placental barrier?
Most drugs with MW < 500 Da cross the placenta, and most drugs with MW > 1000 Da do not cross the placenta (ex.
heparin
, protamine, insulin). Neither succinylcholine (highly ionized) or non-depolarizing NMBDs (high molecular weights) cross the placenta.
What things cross the placenta?
Towards the end of the pregnancy, the placenta passes on antibodies to protect the baby after birth.
Alcohol, nicotine and other drugs and medicines
can cross the placenta and damage your baby.
What is BBB also explain placental barrier?
The placental barrier and the blood brain barrier (BBB)
protect the fetus from pathogens and ensure healthy brain development during pregnancy
.
What is the significance of the placental barrier?
The placenta is the only organ linking two different individuals, mother and fetus, termed as blood-placental barrier. The functions of the blood-placental barrier are
to regulate material transfer between the maternal and fetal circulation
.
Do all drugs pass through the placenta?
Almost every drug passes from the mother’s bloodstream through the placenta to the fetus
. Illicit substances that cause drug dependence and addiction in the mother also cause the fetus to become addicted.
Which trimester does the baby grow the most?
The second trimester
is a time of rapid growth for your baby (called a fetus). Most of the brain’s development begins now and will continue after your baby’s birth.
What are the placental hormones?
Placental hormones include members of
the prolactin and growth hormone family, steroid hormones and neuroactive hormones
. The function of these hormones in driving physiological changes during pregnancy has been assessed in two main ways.
Does physostigmine Cross blood placental barrier?
Physostigmine, the principal antidote for severe anticholinergic toxicity,
crosses the placenta
[4. Drugs in pregnancy and lactation.
Can bacteria cross the placental barrier?
Bacterial or viral infection of the mother during the
course
of pregnancy can cross the placenta and actively infect the fetus.
Which one of the following drugs does not cross the blood placental barrier?
A limited number of drugs reach greater concentrations in fetal than maternal plasma. It is said that these drugs have an ‘exceeding’ transfer. The impression prevails that suxamethonium chloride (succinylcholine chloride) and
doxorubicin
do not cross the placenta.
How can I make my placenta healthy?
This includes lots
of iron-rich foods
as the baby absorbs large amounts of iron from the maternal blood. Consuming nutrient-rich calories and iron rich foods will help to sustain a healthy placenta and prevent conditions such as iron-deficiency anaemia.
What is the name of the fluid that helps to protect the fetus?
Amniotic sac.
The sac is filled with liquid made by the fetus (
amniotic fluid
) and the membrane that covers the fetal side of the placenta (amnion). This protects the fetus from injury. it also helps to regulate the temperature of the fetus.
Do babies get hungry in womb?
Is it Bad When the Baby Moves too Much?
Fetal movements typically increase when the mother is hungry
, reflecting lowered blood sugar levels in the mother and fetus. This is similar to the increased activity of most animals when they are seeking food, followed by a period of quietness when they are fed.
