Hemophilia A and hemophilia B
How is hemophilia inheritance?
It
almost always is inherited (passed down) from a parent to a child
. Both hemophilia A and B are inherited in the same way, because both the genes for factor VIII and factor IX are located on the X chromosome (chromosomes are structures within the body’s cells that contain the genes).
What type of inheritance is hemophilia B?
Hemophilia A and B are inherited as
X-linked recessive genetic disorders
, while hemophilia C is inherited as an autosomal recessive genetic disorder. Autosomal disorders are disorders caused by variations in genes located on non-sex chromosomes (sex chromosomes are the X and Y).
What is hemophilia and how is it inherited?
Hemophilia is an
inherited disease
, most commonly affecting males, that is characterized by a deficiency in blood clotting. The responsible gene is located on the X chromosome, and since males inherit only one copy of the X chromosome, if that chromosome carries the mutated gene then they will have the disease.
What category is Hemophilia?
Hemophilia A: Caused by a lack of the blood clotting factor VIII; approximately 85% of hemophiliacs have
type A disease
. Hemophilia B: Caused by a deficiency of factor IX. Hemophilia C: Some doctors use this term to refer to a lack of clotting factor XI.
Can hemophilia be cured?
There is currently no cure for hemophilia
. Effective treatments do exist, but they are expensive and involve lifelong injections several times per week to prevent bleeding.
Can two normal parents have hemophilic child?
A
family may have children with the hemophilia gene and children without it
. It is also possible for all the children in the family to inherit the normal gene or all to inherit the hemophilia gene.
Is hemophilia A or B worse?
Recent evidence suggests that
hemophilia B is clinically less severe than hemophilia A
, highlighting the need to discuss further therapeutic options for each type of hemophilia. The study, “Haemophilia B is clinically less severe than haemophilia A: further evidence,” was published in Blood Transfusion.
Why Haemophilia B is called Christmas disease?
Hemophilia B is also known as Christmas disease. It is
named after the first person to be diagnosed with the disorder in 1952, Stephen Christmas
. As the second most common type of hemophilia, it occurs in about 1 in 25,000 male births and affects about 4,000 individuals in the United States.
What medication is prescribed for hemophilia B?
Factor IX, recombinant
(BeneFIX, Rixubis, Alprolix, Ixinity, Rebinyn) Recombinant factor IX (rFIX) is indicated for control and treatment of spontaneous or surgery-related bleeding or prevention of bleeding in patients proven to be deficient in FIX.
What foods to avoid if you have hemophilia?
- large glasses of juice.
- soft drinks, energy drinks, and sweetened tea.
- heavy gravies and sauces.
- butter, shortening, or lard.
- full-fat dairy products.
- candy.
- foods containing trans fats, including fried. foods and baked goods (pastries, pizza, pie, cookies, and crackers)
What famous person has hemophilia?
The love of Elizabeth Taylor’s life and a Shakespearean actor for the ages,
Richard Burton
starred in 61 films and 30 plays — and was the first Hollywood star to reveal he had hemophilia. In fact, Burton and Taylor set up the Richard Burton Hemophilia Fund in 1964 to help find a cure for hemophilia.
Why females are not affected by haemophilia?
Hemophilia is a rare blood disease that usually occurs in males. In fact, it’s
extremely rare for women to be born with the condition because of the way it’s passed down genetically
. A female would need to inherit two copies of the faulty gene — one from each parent — to develop hemophilia A, B or C.
What is the life expectancy of someone with hemophilia?
During this period, it exceeded mortality in the general population by a factor of 2.69 (95% confidence interval [CI]: 2.37-3.05), and median life expectancy in severe
hemophilia was 63 years
.
What is the main cause of hemophilia?
Hemophilia is caused
by a mutation or change, in one of the genes
, that provides instructions for making the clotting factor proteins needed to form a blood clot. This change or mutation can prevent the clotting protein from working properly or to be missing altogether. These genes are located on the X chromosome.
What are the 2 deficient factors in hemophilia?
Hemophilia A, B & C: The Three Different Clotting Factor Deficiencies. The two most common types of hemophilia are
factor VIII deficiency
(hemophilia A) and factor IX deficiency (hemophilia B, or Christmas disease).
