Zidovudine may decrease the number of certain cells in
your blood
, including red and white blood cells. Tell your doctor if you have or have ever had a low number of any type of blood cells or any blood disorders such as anemia (a lower than normal number of red blood cells) or bone marrow problems.
What are the side effect of zidovudine?
-
headache;
-
fever, general ill feeling;
-
cough;
-
nausea, vomiting, loss of appetite; or.
-
loss of body fat (especially in your arms, legs, face, and buttocks).
What symptoms side effects of zidovudine need to be reported to the physician?
Call your doctor right away if you or your child have more than one of these symptoms:
abdominal discomfort or cramping, dark urine, decreased appetite, diarrhea
, general feeling of discomfort, light-colored stools, muscle cramping or pain, nausea, unusual tiredness or weakness, trouble breathing, vomiting, or yellow ...
What does zidovudine interact with?
Some products that may interact with this drug include: orlistat, probenecid, ribavirin, stavudine, drugs that may suppress bone marrow function (such as ganciclovir, dapsone, trimethoprim, chemotherapy including doxorubicin, vincristine), drugs that may affect the
kidneys
(including NSAIDs such as ibuprofen or ...
What can I monitor with stavudine?
Monitor HIV RNA levels frequently and if increased HIV viral load confirmed, discontinue orlistat. ritonavir and stavudine both increase risk of immune reconstitution syndrome. Use Caution/Monitor.
saquinavir
and stavudine both increase risk of immune reconstitution syndrome.
Who should not take zidovudine?
-
increased blood acidity due to high levels of lactic acid.
-
anemia.
-
low levels of a type of white blood cell called neutrophils.
-
a disease with shrinking and weaker muscles called myopathy.
-
toxic amblyopia, a loss of vision.
-
liver problems.
-
severe liver disease.
-
muscle inflammation.
When do you give zidovudine?
When should I give zidovudine? Zidovudine is usually given
twice each day
, once in the morning and once in the evening. Ideally, these times are 12 hours apart, for example some time between 7 and 8 am, and between 7 and 8 pm. You can give zidovudine before, with or after food.
What is the other name for zidovudine?
AZT (zidovudine), sold under the brand name
Retrovir
, is a type of anti-HIV (antiretroviral) drug called a nucleoside analogue or “nuke.” AZT is used in combination with other anti-HIV drugs to treat (but not cure) HIV.
Is zidovudine still used?
Zidovudine, also known as azidothymidine (AZT), was the first antiviral to be approved for the treatment of HIV. Although no longer a first-line agent,
zidovudine is still used in combination with other ARVs for the treatment of HIV
[39].
Why are ritonavir and zidovudine taken together?
They
work by decreasing the amount of HIV in the blood
. When lopinavir and ritonavir are taken together, ritonavir also helps to increase the amount of lopinavir in the body so that the medication will have a greater effect.
What nucleoside does zidovudine mimic?
Zidovudine 5-triphosphate is similar in structure to
thymidine triphosphate
, which is normally produced by cells and is one of several nucleoside compounds (structural units of nucleic acids) needed to synthesize DNA.
What are the side effects of lamivudine and zidovudine?
-
headache.
-
diarrhea.
-
heartburn.
-
difficulty falling asleep or staying asleep.
-
depression.
-
stuffy nose.
-
cough.
-
joint pain.
Does aspirin interact with zidovudine?
The
risk or severity of bleeding can be increased when Zidovudine
is combined with Acetylsalicylic acid. The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Zidovudine is combined with Acipimox.
Why zidovudine with stavudine combination is not recommended?
The combination of stavudine (d4T) and didanosine (ddI), initially thought to be
contraindicated because of the overlapping toxicity profiles of the 2 drugs
, was found not only to be safe but to provide more potent antiviral activity than either drug administered alone [1, 2].
What class of drug is stavudine?
Stavudine is used along with other medications to treat human immunodeficiency virus (HIV) infection. Stavudine is in a class of medications called
nucleoside reverse transcriptase inhibitors (NRTIs)
. It works by decreasing the amount of HIV in the blood.
What does 3TC stand for?
What is 3TC? Lamivudine, sold under the brand name 3TC (
Epivir
in the US), is a type of antiretroviral (anti-HIV) drug called a nucleoside analogue or “nuke.” 3TC is used in combination with other antiretroviral drugs to treat (but not cure) HIV.
