When a naïve or memory B cell is activated by an antigen, it proliferates and differentiates into
an antibody-secreting effector cell
, known as a plasmablast or plasma cell. Additionally, B cells present antigens (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines.
Where do B cells differentiate into plasma cells quizlet?
B-cells differentiate into plasma cells in
the lymph nodes and spleen
. Each B-cell has an immunoglobulin receptor capable of binding to one, unique, unprocessed antigen. B-cells secrete interleukins to active themselves, after antigen presentation.
Where does B cell differentiation occur?
activated B cells differentiate into plasma cells in
primary foci that are outside of the follicles
, then migrate to the medullary cords of the lymph node or to the bone marrow. Secrete IgM within 4 days. Other activated B cells enter the follicle, divide and differentiate; germinal centers form.
What causes B cells to differentiate into?
The antigen-dependent phase of B cell development occurs following B cell activation by antigen binding and co-stimulation. These signals promote B cell differentiation into either
memory B cells or terminal, antibody-secreting plasma cells
.
How do B cells fight infection?
B-cells fight bacteria and viruses
by making Y-shaped proteins called antibodies
, which are specific to each pathogen and are able to lock onto the surface of an invading cell and mark it for destruction by other immune cells.
What are B cells for?
B cells are at the centre of the adaptive humoral immune system and are responsible for
mediating the production of antigen-specific immunoglobulin (Ig) directed against
invasive pathogens (typically known as antibodies).
What stimulates the maturation of B cells?
The peptide:MHC class II complex
can be recognized by antigen-specific armed helper T cells, stimulating them to make proteins that, in turn, cause the B cell to proliferate and its progeny to differentiate into antibody-secreting cells.
Do B cells make plasma cells?
A type of immune cell that makes large amounts of a specific antibody. Plasma cells
develop from B cells that have been activated
.
When activated B cells can differentiate into which of the following?
Upon activation, B cells proliferate and form germinal centers where they differentiate into
memory B cells or plasma cells
. Following differentiation into plasma cells, additional signals initiate plasma cell antibody class switching and regulate antibody secretion.
What is differentiation of B cells?
B cell differentiation is tightly controlled by a transcription regulation network. It involves the
coordination of several transcription factors to promote the expression of antibody-secretion and plasma cell-related genes
, and downregulate the B cell identity genes.
How do you activate B cells?
B cells are activated
when their B cell receptor (BCR) binds to either soluble or membrane bound antigen
. This activates the BCR to form microclusters and trigger downstream signalling cascades.
What type of cell is cell B?
B cells are
a type of lymphocyte
that are responsible for the humoral immunity component of the adaptive immune system. These white blood cells produce antibodies, which play a key part in immunity.
How do you keep B cells healthy?
- eating a diet rich in fruits and vegetables.
- exercising regularly.
- maintaining a healthy weight.
- quitting smoking.
- drinking alcohol only in moderation.
- getting enough sleep.
- avoiding infection through regular hand washing.
- reducing stress.
What is normal B cell count?
B Cells (
100-600 cells/μL
; 10-15% of total lymphocytes). These cells are produced from the pluripotent stem cells in the bone marrow and stay in the marrow to mature. B cells are in charge of antibody.
Which blood cell types live longer?
Blood cells constantly die and your body makes new ones.
Red blood cells
live about 120 days, and platelets live about 6 days. Some white blood cells live less than a day, but others live much longer.
What are the two main functions of B cells?
- to make antibodies against antigens,
- to perform the role of antigen-presenting cells (APCs),
- to develop into memory B cells after activation by antigen interaction.
