A frameshift mutation is produced either by
insertion or deletion of one or more new bases
. Because the reading frame begins at the start site, any mRNA produced from a mutated DNA sequence will be read out of frame after the point of the insertion or deletion, yielding a nonsense protein.
Which of the following is an example of a frameshift mutation?
Which of the following is an example of a frameshift mutation? Answer a.
The deletion of one nucleotide
is an example of a frameshift mutation.
Which of the following would result in a frameshift mutation?
Frameshift mutations arise when
the normal sequence of codons is disrupted by the insertion or deletion of one or more nucleotides
, provided that the number of nucleotides added or removed is not a multiple of three.
What is the most common result of a frameshift mutation?
In some instances, the addition and the deletion of nucleotides occur simultaneously (known as double frameshift), which eventually restore the reading frame to normal. The outcome of the frameshift mutation may be
a complete loss of protein structure and functionality
, resulting in the non-functional polypeptide.
What is a frameshift mutation and how does it affect the protein?
Frameshift mutations are the result of
insertions or deletions that alter the reading frame of the triplet codons
, thereby altering translation and altering the structure and function of the protein product.
What occurs during frameshift mutation?
Frameshift mutations arise when
the normal sequence of codons is disrupted by the insertion or deletion of one or more nucleotides
, provided that the number of nucleotides added or removed is not a multiple of three.
What occurs in a deletion mutation?
A deletion mutation occurs when
a wrinkle forms on the DNA template strand and subsequently causes a nucleotide to be omitted from the replicated strand
(Figure 3). Figure 3: In a deletion mutation, a wrinkle forms on the DNA template strand, which causes a nucleotide to be omitted from the replicated strand.
What is a frameshift mutation easy definition?
A frameshift mutation is
a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three
. “Divisible by three” is important because the cell reads a gene in groups of three bases.
What are the types of mutation?
Types of Mutations
There are three types of DNA Mutations:
base substitutions, deletions and insertions
.
What is an example of point mutation?
For example,
sickle-cell disease
is caused by a single point mutation (a missense mutation) in the beta-hemoglobin gene that converts a GAG codon into GUG, which encodes the amino acid valine rather than glutamic acid.
What is the difference between frameshift mutation and point mutation?
Chromosomal alterations are mutations that change chromosome structure. Point mutations
change a single nucleotide
. Frameshift mutations are additions or deletions of nucleotides that cause a shift in the reading frame.
What is an example of silent mutation?
Silent mutations are base substitutions that result in no change of the amino acid or amino acid functionality when the altered messenger RNA (mRNA) is translated. For example, if the
codon AAA is altered to become AAG
, the same amino acid – lysine – will be incorporated into the peptide chain.
Which type of mutation is most harmful?
Deletion mutations, on the other hand, are opposite types of point mutations. They involve the removal of a base pair. Both of these mutations lead to the creation of the most dangerous type of point mutations of them all:
the frameshift mutation
.
What is an example of deletion mutation?
Deletions are responsible for an array of genetic disorders, including some cases of male infertility,
two thirds of cases of Duchenne muscular dystrophy
, and two thirds of cases of cystic fibrosis (those caused by ΔF508). Deletion of part of the short arm of chromosome 5 results in Cri du chat syndrome.
What are four types of chromosomal mutations?
- deletion is where a section of a chromosome is removed.
- translocation is where a section of a chromosome is added to another chromosome that is not its homologous partner.
- inversion is where a section of a chromosome is reversed.
Which type of mutation does not change the overall function of the protein?
A mutation that results in no protein function is called a
null mutation
. Changes that do not affect the function of a protein are called silent mutations.
