Sibutramine is recommended for
obese patients
with an initial body mass index ≥ 30 kg/m2, or ≥ 27 kg/m2 in the presence of other risk factors (e.g., diabetes, dyslipidemia, controlled hypertension). Sibutramine assists with weight-loss by altering neurotransmitters within the brain.
What are the contraindications of sibutramine?
- diabetes.
- increased risk of bleeding due to clotting disorder.
- anorexia nervosa.
- bulimia.
- neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion.
- serotonin syndrome, a type of disorder with high serotonin levels.
- closed angle glaucoma.
- high blood pressure.
Who should not take sibutramine?
Do not use sibutramine if you have taken an MAO inhibitor such as
furazolidone
(Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days.
How much sibutramine should I take?
The recommended starting dose of MERIDIA (sibutramine hydrochloride monohydrate) is
10 mg administered once daily
with or without food. If there is inadequate weight loss, the dose may be titrated after four weeks to a total of 15 mg once daily.
How safe is sibutramine?
Sibutramine is
safe and effective for weight loss in obese patients
whose hypertension is well controlled with angiotensin-converting enzyme inhibitors. J Hum Hypertens.
Where is sibutramine banned?
Sibutramine was a prescription-only weight loss medicine in
Singapore
but has been banned since 2010 due to an increased risk of heart attack and strokes. Other serious adverse effects reported in the past by consumers who took products adulterated with sibutramine include insomnia and hallucinations.
How long does sibutramine stay in your body?
| Clinical data | Protein binding 97%, (94% for its desmethyl metabolites, M 1 & M 2 ) | Metabolism Hepatic (CYP3A4-mediated) | Elimination half-life 1 hour (sibutramine), 14 hours (M 1 ) & 16 hours (M 2 ) | Excretion Urine (77%), feces (8%) |
|---|
Is sibutramine still on the market?
Sibutramine was withdrawn from the U.S. market in October 2010
. Sibutramine affects chemicals in the brain that affect weight maintenance. Sibutramine is used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.
Can you overdose on sibutramine?
Sibutramine is a synthetic noradrenaline, dopamine, and serotonin reuptake inhibitor used for the treatment of obesity. FDA and European Medicines Agency banned it because of its cardiovascular risks [1, 3, 4].
Tachycardia, hypertension, headache, and dizziness have been reported with sibutramine overdose
[1, 5].
How much weight can you lose with sibutramine?
At 1 year, adults receiving sibutramine, 10 to 15 mg/d, lost an
average of 4.5 kg
(9.8 pounds) more than adults receiving placebo. Adults taking sibutramine for 1 year are 19% to 34% more likely to achieve 5% weight loss and 12% to 31% more likely to achieve 10% weight loss than those taking placebo.
Does sibutramine give you energy?
Sibutramine is a serotonin and noradrenaline reuptake inhibitor that
reduces energy intake by creating a satiated feeling
and increases energy expenditure by enhancing thermogenesis.
How does sibutramine affect erectile dysfunction?
Background: It is well known that selective serotonin reuptake inhibitors (SSRIs) can cause sexual dysfunction, so it is possible that sibutramine, a serotonin and norepinephrine reuptake inhibitor,
could induce sexual dysfunction
.
Does sibutramine affect fertility?
The epididymal norepinephrine depletion exerted by sibutramine, associated with decreases in sperm transit time, quantity and quality, leading
to reduced fertility in this experimental model
, reinforces the concerns about the possible impact on fertility of man taking sibutramine as well as other non-selective …
Is sibutramine legal in Canada?
Sibutramine is no longer authorized for sale in Canada
because of its association with an increased risk of cardiovascular side effects such as heart attack and stroke.
Is sibutramine legal in Australia?
Following discussions with the Therapeutic Goods Administration (TGA), Abbott Australasia will
cease
supply of sibutramine (Reductil) in Australia from 9 October 2010. Sibutramine, marketed in Australia as Reductil, is a prescription medicine indicated for weight loss.
Does orlistat help lose weight?
Does orlistat work? Studies have shown that, on average, orlistat, plus a weight-reducing diet and exercise,
causes more weight loss than
a weight-reducing diet and exercise alone. Some people lose 10% or more of their body weight within six months with the help of orlistat.
