Quinine, a known antimalarial drug, has been used for nocturnal leg cramps since the 1930s; it is associated with severe life-threatening hematological and cardiovascular side effects . Disseminated intravascular coagulation (DIC), albeit rare, is a known coagulopathy associated with Quinine.
Does tonic water interfere with blood thinners?
are taking medications, such as blood thinners, antidepressants, antibiotics, antacids, and statins (these medications may not preclude you from taking quinine or drinking tonic water, but you should tell your doctor about these and any other medications you take if you’re prescribed quinine)
Can I take quinine with blood thinners?
A. Coumadin (warfarin) and quinine are a no-no! When these compounds are combined, the anticoagulant effect may be magnified. There are cases of hemorrhage associated with this interaction.
What drugs should not be taken with quinine?
Other medications can affect the removal of quinine from your body, which may affect how quinine works. Examples include cimetidine, erythromycin , ketoconazole, phenytoin, rifampin, HIV protease inhibitors (such as lopinavir, ritonavir), urinary alkalinizers such as sodium bicarbonate, among others.
How does quinine affect warfarin?
Using quiNINE together with warfarin can cause you to bleed more easily . You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR).
What drugs interact with quinine?
- Serious interactions of quinine include:
- cisapride.
- dronedarone.
- eliglustat.
- pimozide.
- thioridazine.
What blood disorder does quinine cause?
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G-6-PD); myasthenia gravis ; optic neuritis (inflammation of the optic nerve); or. if you have taken quinine in the past and it caused a blood cell disorder, severe bleeding, or kidney problems.
What does quinine do to the human body?
Quinine is used to treat malaria caused by Plasmodium falciparum . Plasmodium falciparum is a parasite that gets into the red blood cells in the body and causes malaria. Quinine works by killing the parasite or preventing it from growing.
Why was quinine taken off the market?
In early 2007, FDA banned all prescription quinine products other than Qualaquin. FDA acted in this manner because of a perception that quinine is not effective for this condition and that its risk potential far exceeds its efficacy potential.
Is quinine bad for your heart?
Conclusions: Use of quinine was common and associated with increased mortality in heart failure , especially if administered together with β-blockers and shortly after treatment initiation.
Does quinine help leg cramps?
Quinine sulfate, an antimalarial drug, is widely used as an effective therapy for idiopathic leg cramps .
Is there an alternative to quinine for night cramps?
Quinine should not be used to treat nocturnal leg cramps. Carisoprodol (Soma) , diltiazem, gabapentin (Neurontin), magnesium, orphenadrine (Norflex), verapamil, and vitamin B 12 complex may be useful in some patients with nocturnal leg cramps.
When should you take blood thinners?
Your doctor may recommend taking a blood thinner if you have heart disease , including heart valve disease, and irregular heart rhythms
What are the negative effects of quinine?
- Blurred vision.
- change in color vision.
- changes in behavior.
- confusion.
- diarrhea.
- hearing loss.
- ringing in the ears.
- stomach cramps or pain.
What are the long term effects of taking quinine?
Long-term off-label use of quinine, still prescribed to individuals with muscle cramps despite Food and Drug Administration warnings of adverse events, is associated with an increased risk of death , according to a study published by JAMA.
Is quinine good for the liver?
According to medical professionals, quinine should not be taken by people suffering from low blood sugar, abnormal heart rhythms, kidney disease, or liver disease.
