The effects of this medication are short-lived, meaning they will stop working
within 24 hours
, although the benefits may be prolonged if your animal has decreased kidney and/or liver function.
What does cisapride do for a dog?
Cisapride has been used widely to
treat gastric-emptying disorders, intestinal transit and other motility disorders
in both dogs and cats. It accelerates emptying the stomach and propulsion of food through the intestines by increasing peristalsis. Cisapride is used in cats to manage chronic constipation and megacolon.
Is cisapride safe for dogs?
Cisapride is generally well tolerated in cats and dogs
. The most common side effects are vomiting, diarrhea or abdominal pain.
What are the side effects of cisapride?
The most common side effects associated with cisapride are
headache, diarrhea, stomach pain, nausea, constipation, and a runny nose
. Other side effects have been reported less frequently. Be sure to ask your doctor or pharmacist about the side effects of any medication you are taking, including cisapride.
Why is cisapride banned?
Janssen Pharmaceutica, in consultation with the FDA, has decided to stop marketing the prokinetic agent cisapride (Propulsid®) on July 14, 2000
due to the risk of serious cardiac arrhythmias and death associated with this agent
.
What can be used instead of cisapride?
Many currently available medications have equivalent or greater efficacy than cisapride for indications such as gastro-oesophageal reflux disease, functional dyspepsia, oesophageal dysmotility and constipation. The alternatives include
acid suppressing drugs, domperidone, metoclopramide and laxatives
.
When do you give cisapride?
Cisapride is used in cats to manage chronic constipation and megacolon. Work in humans has shown that cisapride is better absorbed when given with food. In small-animal practice it usually is recommended that cisapride be given orally
15 minutes before feeding
.
Is cisapride a laxative?
As a prokinetic agent
Is there a replacement for Propulsid?
Dr. Marks: The only prokinetic agent
What kind of drug is cisapride?
Propulsid Side Effects Center. Propulsid (cisapride) is
a “prokinetic” agent
that increases muscle contractions of the lower esophagus and the lower esophagus sphincter used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn.
What are side effects of domperidone?
- diarrhea.
- headache.
- drowsiness.
- dry mouth.
- stomach cramps.
- discomfort and fullness of the breasts; this is an expected side effect for the purpose of increasing your breast milk.
- rash or hives.
Is Reglan a serotonin antagonist?
Metoclopramide is principally a
dopamine D
2
antagonist
but also acts as an agonist on serotonin 5-HT
4
receptors and causes weak inhibition of 5-HT
3
receptors.
Can cisapride cause diarrhea?
Side effects are uncommon but vomiting, diarrhea, or gastrointestinal discomfort may occur. More serious side effects include incoordination, excessive drooling, muscle twitches, agitation, abnormal behavior, increased body temperature, and seizures; these signs may indicate doses are too high.
Is megacolon reversible?
In most cases,
megacolon is reversible
. This depends on whether it is possible to treat the underlying cause. In acute and toxic megacolon, the underlying cause can usually be treated or otherwise resolves itself naturally, so dilation of the colon is reversed.
How do you cure megacolon naturally?
Empty the bowel
(eg, osmotic laxatives, enemas, suppositories, cathartics, digital disimpaction). Practice a bowel habit retraining program (eg, scheduled times for defecation, increased physical activity if possible). Consume bulking agents/bowel agents. Slowly alter/individualize the regimen.
Does cisapride expire?
Conclusions: Cisapride was stable in a suspension for 91 days at 4 degrees C and
28 days at 25 degrees C
in amber plastic prescription bottles.
