Ranitidine , a new H2-receptor blocking antihistamine, is pharmacokinetically similar to cimetidine, but its potency is about eightfold greater. The clinical response to ranitidine is more prolonged, largely because of potency and not kinetic advantage.
Why is ranitidine preferred over cimetidine?
These studies show that ranitidine can adequately inhibit acid secretion in patients with gastric hypersecretory disorders, is safe at high doses, does not cause the antiandrogen side effects frequently seen with high doses of cimetidine, and is threefold more potent than cimetidine.
Does cimetidine have ranitidine in it?
Tagamet (cimetidine) and Zantac (ranitidine hydrochloride) are histamine receptor antagonists used to treat and prevent ulcers.
What is the brand name for cimetidine?
BRAND NAME (S): Tagamet . USES: Cimetidine is used to treat ulcers of the stomach and intestines and prevent them from coming back after they have healed.
What is equivalent to ranitidine?
There are three PPIs that the FDA lists as alternatives to ranitidine and nizatidine: Esomeprazole (brand name Nexium) Lansoprazole (brand name Prevacid) Omeprazole (brand name Prilosec)
Why is cimetidine banned?
The FDA said the medicines may contain “unacceptable” amounts of N-Nitrosodimethylamine (NDMA), a substance the World Health Organization has classified as a “ probable human carcinogen .”
Is cimetidine stronger than ranitidine?
Ranitidine, a new H2-receptor blocking antihistamine, is pharmacokinetically similar to cimetidine, but its potency is about eightfold greater . The clinical response to ranitidine is more prolonged, largely because of potency and not kinetic advantage.
Is cimetidine discontinued?
Cimetidine 200mg tablets are out of stock until the end of January 2020 . Nizatidine 150mg and 300mg tablets are out of stock until February 2020.
Is cimetidine an antihistamine?
CIMETIDINE (sye MET i deen) is a type of antihistamine that blocks the release of stomach acid. It is used to treat stomach or intestinal ulcers.
Is famotidine more potent than ranitidine?
These studies demonstrate that famotidine is nine times more potent than ranitidine and 32 times more potent than cimetidine, has a longer duration of action than ranitidine or cimetidine, and is both safe and effective in the long-term therapy of Zollinger-Ellison syndrome.
Which is safer omeprazole or cimetidine?
Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis. Aliment Pharmacol Ther. 1997 Aug;11(4):755-63. doi: 10.1046/j.
Is it safe to take cimetidine long term?
Do not take over-the-counter cimetidine for longer than 2 weeks unless your doctor tells you to . If symptoms of heartburn, acid indigestion, or sour stomach last longer than 2 weeks, stop taking cimetidine and call your doctor.
Is Tagamet bad for your kidneys?
They lower the amount of acid in your stomach, but studies have shown that taking them for a long time can raise your chances of serious kidney problems and possibly lead to kidney failure . Other heartburn medicines called H2 blockers (Pepcid, Tagamet, Zantac) are less likely to cause these issues.
Why was ranitidine taken off the market?
Officials at the Food and Drug Administration (FDA) have ordered all ranitidine medications, sold under the brand name Zantac, taken off store shelves immediately. The order is tied to concerns that the medication may contain a cancer-causing chemical that’s also been detected in certain blood pressure medications .
Is all ranitidine being recalled?
The FDA has requested all ranitidine (Zantac) products be pulled from the market immediately . The recall includes all prescription and over-the-counter ranitidine drugs as ongoing investigations uncovered levels of N-Nitrosodimethylamine (NDMA), a probable human carcinogen, increase over time.
Which works better ranitidine or omeprazole?
Conclusions: After 6 weeks of ranitidine treatment, the majority of patients with GERD were still experiencing moderate to severe heartburn. Omeprazole was significantly more effective than ranitidine in resolving heartburn in this group of patients.
