Merck sells the DPP-4 inhibitor sitagliptin (Januvia). Merck also sells a combination DPP-4/SGLT2 inhibitor, sitagliptin/ertugliflozin (Steglujan).
Is Januvia a SGLT2 drug?
MUNICH — For type 2 diabetes patients uncontrolled on metformin and
sitagliptin
(Januvia), adding the novel sodium/glucose cotransporter 2 (SGLT2) inhibitor ertugliflozin improved glycemic levels, a trial showed.
Is Sitagliptin a SGLT2 inhibitor?
The US Food and Drug Administration has approved Steglatro (ertugliflozin) tablets, an oral sodium-glucose co-transporter 2
(SGLT2)
inhibitor, and the fixed-dose combination Steglujan (ertugliflozin and sitagliptin) tablets, which have been developed by US pharma giants Merck & Co (NYSE: MRK) and Pfizer (NYSE: PFE).
What class of drugs is Januvia?
Januvia is a prescription medicine used to treat the symptoms of Type 2 Diabetes Mellitus. Januvia may be used alone or with other medications. Januvia belongs to a class of drugs
Antidiabetics, Dipeptyl Peptidase-IV Inhibitors
.
What are the brand names for SGLT2 inhibitors?
- canagliflozin (Invokana)
- canagliflozin/metformin (Invokamet)
- canagliflozin/metformin extended release (Invokamet XR)
- dapagliflozin (Farxiga)
- dapagliflozin/metformin extended release (Xigduo XR)
- dapagliflozin/saxagliptin (Qtern)
Which SGLT2 is best?
Current Selective SGLT2 Inhibitors
Of the three FDA approved drugs,
empagliflozin
has the greatest selectivity for SGLT2 compared to SGLT1, while canagliflozin is the least selective (5).
Are any SGLT2 inhibitors generic?
There are currently no generic alternatives to Invokana
. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Farxiga (dapagliflozin) helps to treat type 2 diabetes, heart failure, and chronic kidney disease. It helps to control blood sugar.
Can you combine SGLT2 and DPP4?
In conclusion, the SGLT2 inhibitor and DPP4 inhibitor combination therapy
improves glycemic control
and reduces body weight without increasing the risk of hypoglycemia and UTI in patients with inadequately controlled type 2 diabetes.
Can SGLT2 and DPP4 be used together?
DPP-4 inhibitors and SGLT2 inhibitors lower blood glucose by complementary mechanisms of action, and two fixed-dose combinations – Qtern and Glyxambi – have now been approved for the treatment of
type 2 diabetes
.
Is Januvia a DPP-4?
Called DPP-
4
inhibitors, these drugs work in a way that is different from any previous diabetes treatment. Sitagliptin (brand name Januvia) was the first drug in this class to be approved; it can be used alone or in combination with other oral diabetes drugs.
Is Januvia bad for your kidneys?
No clinical studies have linked the use
of Januvia to kidney problems.
Who should not take Januvia?
- low blood sugar.
- acute inflammation of the pancreas.
- chronic inflammation of the pancreas.
- chronic kidney disease stage 3B (moderate)
- chronic kidney disease stage 4 (severe)
- chronic kidney disease stage 5 (failure)
- kidney disease with likely reduction in kidney function.
Is Januvia better than metformin?
Summary. Januvia and metformin are both effective drugs that are used to help manage blood sugar levels in patients with type 2 diabetes. Although both drugs can cause serious side effects, there are fewer side effects associated with Januvia and
the drug is better tolerated than metformin
.
Who should not take SGLT2 inhibitors?
Prescribing SGLT2 inhibitors should be restricted if the patient has a history of
type 1 DM
, ketosisprone T2DM, and in those with a glomerular filtration rate of
Which SGLT2 is best for heart failure?
Dapagliflozin
is the only SGLT2 inhibitor to demonstrate a significant and clinically meaningful reduction in both the CV death and worsening HF components of the primary composite endpoint in patients with HFrEF, both with and without T2D.
How much do SGLT2 lower A1C?
Compared with placebo, SGLT2 inhibitors reduce hemoglobin A1c (HbA1c) levels
by an average of 0.5%-0.8%
when used as monotherapy or add-on therapy.
