THOUSAND OAKS, Calif. , June 29, 2017 /PRNewswire/ — Amgen (NASDAQ:AMGN) today announced that the U.S. Food and Drug Administration ( FDA ) has approved the
supplemental Biologics License Application
(sBLA) for Vectibix
®
(panitumumab) for patients with wild-type RAS (defined as wild-type in both KRAS and NRAS as …
When do you use panitumumab?
Panitumumab is indicated for use in
patients with wild-type rather than mutant KRAS tumours
. The efficacy of intravenous panitumumab 6 mg/kg administered every 2 weeks was examined in randomized, open-label, multicentre, phase III trials in patients with metastatic colorectal cancer.
What type of drug is panitumumab?
Panitumumab is used to treat a type of cancer of the colon or rectum that has spread to other areas of the body either during or after treatment with other chemotherapy drugs. Panitumumab is in a class of medications called
monoclonal antibodies
. It works by slowing or stopping the growth of cancer cells.
How much does panitumumab cost?
Panitumumab costs
£379.29 per 5-ml vial and £1,517.16 per 20-ml vial
(excluding VAT, BNF online October 2015). The company has agreed a patient access scheme with the Department of Health, providing a simple discount to the list price of panitumumab with the discount applied at the point of purchase or invoice.
How effective is panitumumab?
Conclusion. Panitumumab monotherapy is an
effective and well tolerated treatment of metastatic colorectal cancer
in extensively pretreated KRAS wild-type patients. Our data have shown a response to panitumumab monotherapy for more than 11 months.
How fast does panitumumab work?
You have panitumumab every 2 weeks. The first treatment takes
about 60 to 90 minutes
. If you don’t have any problems treatments after that take about 30 to 60 minutes. You usually have panitumumab for as long as it is helping you and the side effects aren’t too bad.
What is the success rate for immunotherapy?
Immunotherapy drugs work better in some cancers than others and while they can be a miracle for some, they fail to work for all patients. Overall response rates are
about 15 to 20%
.
What are the side effects of panitumumab?
- Anxiety.
- bloating or swelling of the face, arms, hands, lower legs, ankles, or feet.
- convulsions.
- decreased urination.
- deep cracks, grooves, or lines in the skin.
- difficulty with swallowing.
- discoloration of the fingernails or toenails.
- drowsiness.
Is panitumumab an immunotherapy?
Immunotherapy with monoclonal
antibodies, such as panitumumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving niraparib and panitumumab may work better in treating patients with colorectal cancer.
Who manufactures panitumumab?
Panitumumab (INN), formerly ABX-EGF, is a fully human monoclonal antibody specific to the epidermal growth factor receptor (also known as EGF receptor, EGFR, ErbB-1 and HER1 in humans). Panitumumab is manufactured by
Amgen
and marketed as Vectibix. It was originally developed by Abgenix Inc.
Is panitumumab targeted therapy?
Panitumumab is a
targeted therapy that targets
and binds to the epidermal growth factor receptors (EGFR) on the surface of the cell. EGFR is found on the surface of many normal and cancer cells.
What is Vectibix used to treat?
Vectibix is used to treat
colorectal cancer that has spread
. It is used to treat colon cancers that express EGFR and disease that has gotten worse either on or following fluoropyrimidine, oxaliplatin and irinotecan containing chemotherapy regimens.
Does Vectibix shrink tumors?
Objective response rate, which is the percentage of patients who experienced tumor size reduction, was
22 percent for
patients treated with Vectibix compared to 19.8 percent for patients treated with Erbitux.
Is Vectibix a chemotherapy?
About Vectibix
®
(panitumumab)
With this approval, Vectibix became
the first-and-only biologic therapy indicated for use
with FOLFOX, one of the most commonly used chemotherapy regimens, in the first-line treatment of mCRC for patients with wild-type KRAS mCRC.
How do you treat Vectibix rash?
Treatment Recommendations
Prevention of acneiform rash caused by EGFR inhibitors includes topical corticosteroids (hydrocortisone 2.5%, alclometasone) and
oral antibiotics (minocycline, doxycycline, or antibiotics covering skin flora)
twice daily for at least the first 6 weeks.
Do you lose your hair on Folfiri?
You could lose all your hair
. This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. Your hair will usually grow back once treatment has finished but it is likely to be softer.
