How Do Anthracyclines Work?
How Do Anthracyclines Work? Anthracyclines are a class of potent and widely used cytotoxic drugs, derived from antibiotics that inhibit DNA and RNA synthesis by intercalating between base pairs of the DNA/RNA strand. They create iron-mediated free oxygen radicals, damaging the DNA and cell membranes, and inhibit topoisomerase II. Are plant alkaloids alkylating agents? Plant