Does Divalproex Cause Hyponatremia?

Does Divalproex Cause Hyponatremia? Does divalproex cause hyponatremia? In total, 87 cases of hyponatremia were identified from 630 adverse drug reactions. Six of these cases were patients who were using divalproex, or 6.9% of all hyponatremia cases. Each of the 6 patients who experienced severe hyponatremia were those using both DVP and another antiepileptic agent.