Can Stress Cause Spotting On Depo?

Can Stress Cause Spotting On Depo? Can stress cause spotting on Depo? Stress: Stress can cause an increase in cortisol, a hormone that interferes with the release of estrogen and progesterone, which can disrupt the menstrual cycle and lead to spotting. Is random spotting normal on Depo? Irregular bleeding is normal on Depo-Provera. Around 57