Can Metabolic Acidosis Precipitate Cycle Cell Crisis?
Can Metabolic Acidosis Precipitate Cycle Cell Crisis? Acidosis is well recognized as a promoter of HbS polymerization and therefore red blood cell sickling. Indeed, it has been shown in vitro that the relative amount of sickled red blood cells increases markedly from 1% at pH 7.4 to >90% at pH 7.0. Does sickle cell anemia