Is Familial Hypercholesterolemia Life-threatening?

Is Familial Hypercholesterolemia Life-threatening? Familial hypercholesterolemia (FH) is a common life-threatening genetic condition that causes high cholesterol. Untreated, FH leads to early heart attacks and heart disease. What is the life expectancy of someone with familial hypercholesterolemia? A: Without treatment, the life expectancy of those with familial hypercholesterolemia can be reduced by approximately 15-30 years.