What Is Considered A Narrow Therapeutic Index? • Narrow therapeutic index (NTI) drugs are defined as those drugs where. small differences in dose or blood concentration may lead to dose and blood concentration dependent, serious therapeutic failures or adverse drug reactions. Is high therapeutic index Good or bad? The larger the TI, the safer the
What Is Considered A Safe Therapeutic Index? Term Meaning TR Therapeutic Ratio Is high therapeutic index Good or bad? The larger the TI, the safer the drug is. Conversely, a drug with a narrow TI has generally a steep concentration–response relationship for efficacy, toxicity or both so that there is a narrowly defined range between
Is A High Or Low Therapeutic Index Better? A higher therapeutic index is preferable to a lower one: a patient would have to take a much higher dose of such a drug to reach the toxic threshold than the dose taken to elicit the therapeutic effect. Is a higher therapeutic index better? A ratio that