| Acronym Definition | POMC Proopiomelanocortin | POMC Parents of Murdered Children | POMC Port of Melbourne Corporation (Melbourne, Australia) | POMC National Organization of Parents Of Murdered Children, Inc. (since 1978; Cincinnati, Ohio) |
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What hormone is POMC?
Proopiomelanocortin (POMC) is the pituitary precursor of
circulating melanocyte stimulating hormone (α-MSH)
, adrenocorticotropin hormone (ACTH), and β-endorphin.
What does POMC code for?
POMC (Proopiomelanocortin) is a Protein Coding gene. Diseases associated with POMC include
Obesity, Early-Onset
, With Adrenal Insufficiency And Red Hair and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Adipocytokine signaling pathway and Peptide ligand-binding receptors.
What is a POMC neuron?
The arcuate pro-opiomelanocortin (POMC) neurons in particular have been shown to be
critical regulators of metabolism and reproduction
because of their projections to several brain areas both in and outside of the hypothalamus, such as autonomic regions of the brain stem and spinal cord.
What is POMC deficiency?
Proopiomelanocortin (POMC) deficiency
causes severe obesity that begins at an early age
. In addition to obesity, people with this condition have low levels of a hormone known as adrenocorticotropic hormone (ACTH) and tend to have red hair and pale skin.
Why is POMC important?
However, POMC products (the MSHs, ACTH and β-endorphin) also have important roles in
the skin, stress response, immune system and sexual function
[1–6]. Experimental evidence suggests that POMC neurones form an integral part of the central melanocortin system regulating feeding behaviour.
Is POMC a neurotransmitter?
POMC neurons extend projections along the rostrocaudal axis of the brain, and can signal with both POMC-derived peptides and
fast amino acid neurotransmitters
.
What is produced from POMC?
One peptide produced from the POMC protein is called
adrenocorticotropic hormone (ACTH)
. ACTH binds to melanocortin 2 receptor (MC2R), stimulating the release of a hormone called cortisol. This hormone helps maintain blood sugar levels, protects the body from stress, and stops (suppresses) inflammation.
What is ACTH do?
Adrenocorticotropic hormone (ACTH) is a
hormone that stimulates the production of cortisol
. Cortisol is a steroid hormone made by the adrenal glands that is important for regulating glucose, protein, and lipid metabolism, suppressing the immune system’s response, and helping to maintain blood pressure.
Where are POMC neurons located?
EGFP neurons are located in
the ARC of the hypothalamus and in the NTS of the caudal brainstem of
POMC-EGFP reporter mice.
Is NPY a hormone?
Neuropeptide Y is considered to be an
anxiolytic endogenous peptide
and its levels can be modulated by stress. NPY has connections to the HPA axis and is believed to be necessary for stress modulation. It has been shown that higher levels of the Y1 and Y5 receptors in the amygdala result in reduced level of anxiety.
How are POMC neurons activated?
ARC POMC neurons are activated by
leptin and glucose
(Cowley et al., 2001; Ibrahim et al., 2003; Parton et al., 2007). These neurons may modulate feeding- and activity-related neural circuits by responding to slow metabolic cues in the hypothalamus.
Where is POMC made?
POMC is synthesized by
the corticotrophs of the anterior pituitary
, which constitute about 10 percent of the gland. The molecule is split into several biologically active polypeptides when the secretory granules are discharged from the corticotrophs. Among these polypeptides is ACTH, whose major…
What symptoms would a person deficient in leptin have?
Leptin receptor deficiency is a condition that causes
severe obesity
beginning in the first few months of life. Affected individuals are of normal weight at birth, but they are constantly hungry and quickly gain weight. The extreme hunger leads to chronic excessive eating (hyperphagia) and obesity.
What is dog POMC?
The POMC gene codes for two proteins,
beta-MSH (melanocyte-stimulating hormone) and beta-endorphin
. These proteins are thought to play a role in satiety (signaling the brain to end the sensation of hunger once a dog eats a meal).
How is leptin receptor deficiency treated?
Congenital leptin deficiency can be successfully treated with
daily subcutaneous injections of recombinant human leptin
, resulting in sustained positive effects on weight loss, reducing appetite, appropriate pubertal development and hyperinsulinaemia.
