Von Willebrand factor testing includes
VWF antigen
, which measures the amount of VWF, and VWF activity (also known as Ristocetin Cofactor), which evaluates the function of VWF. Some laboratories may offer a panel that includes both of these tests along with a factor VIII activity test.
What is von Willebrand disease profile?
A von Willebrand factor (vWF) antigen test measures the quantity of a protein called von Willebrand factor that
helps blood to clot
. A clot is a lump of blood that the body produces to prevent excessive bleeding by sealing leaks in blood vessels caused by wounds, cuts, scratches, and other conditions.
What is von Willebrand comprehensive panel?
What is this test? This panel of tests is
used to diagnose von Willebrand disease
. This is a bleeding disorder that causes excessive bleeding from minor injuries or normal physical processes such as menstruation. It's the most common inherited bleeding disorder, but few people with the disease have symptoms.
What are the laboratory findings of von Willebrand diseases?
Laboratory characteristics of type 1 VWD include
a mild to moderate but proportional decrease in both VWF:Ag and VWF:RCo
. FVIII:C may be normal or borderline low. Bleeding symptoms range from mild mucosal bleeding to more severe surgical hemorrhage. Bleeding and penetrance in type 1 VWD is variable.
How long does it take to get von Willebrand results?
It may take
up to one week
for your doctor to receive the blood test results. If any of the results suggest a bleeding disorder, the doctor may recommend repeating certain tests and that family members also be tested to see if they have the condition.
At what age is von Willebrand disease diagnosed?
76% of men with VWD had been diagnosed by
age 10
, but 50% of women with VWD were not diagnosed until after age 12.
How much does von Willebrand test cost?
Results: The cost of testing adolescents with menorrhagia for VWD was
$1790
, versus $1251 for not testing for VWD. The effectiveness of not testing in quality-adjusted life-years (QALYs) gained (14.237 QALYs) was similar to the VWD testing strategy (14.246 QALYs).
Can von Willebrand disease go away?
Von Willebrand factor helps blood cells stick together (clot) when you bleed. If there's not enough of it or it does not work properly, it takes longer for bleeding to stop.
There's currently no cure for VWD
, but it does not usually cause serious problems and most people with it can live normal, active lives.
Can you take ibuprofen with von Willebrand disease?
Treatment depends on the type of von Willebrand's disease you have, how much you bleed, and your risk for heavy bleeding. You may need to:
Avoid
nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen (Advil or Motrin, for example), and naproxen (Aleve).
How is von Willebrand disease different from hemophilia?
Like hemophilia, VWD is passed on through the genes from parent to child. But unlike hemophilia,
men and women have an equal chance of getting VWD
. It is possible for a person to have both von Willebrand Disease and hemophilia. Unlike hemophilia, people with VWD rarely bleed into their joints.
What is the prognosis of von Willebrand disease?
Outlook / Prognosis
Von Willebrand disease is
a lifelong condition
. For most people with the disease it doesn't interfere with living active lives. Usually, it only needs to be addressed after a severe injury or if you need surgery.
What are the different types of von Willebrand disease?
There are three main types of VWD (
VWD type 1, VWD type 2, and VWD type 3
) each with differing degrees of severity and inheritance patterns. Unlike hemophilia which is characterized by joint bleeding, VWD is typically characterized by mucocutaneous bleeding.
How does von Willebrand disease affect the body?
Von Willebrand disease is a lifelong
bleeding disorder in which your blood doesn't clot well
. People with the disease have low levels of von Willebrand factor, a protein that helps blood clot, or the protein doesn't perform as it should.
How do you rule out von Willebrand disease?
To find out if a person has von Willebrand disease (VWD),
the doctor will ask questions about personal and family histories of bleeding
. The doctor also will check for unusual bruising or other signs of recent bleeding and order some blood tests that will measure how the blood clots.
What is the normal range for von Willebrand factor?
In the general population, the mean level of plasma VWF is 100 IU per dL, with a normal reference range
between 50 and 200 IU per dL
.
What happens to clotting time in von Willebrand's disease?
When a person has VWD, because the VWF doesn't work the way it should,
the clot might take longer to form or form incorrectly
and bleeding might take longer to stop. This can lead to heavy, hard-to-stop bleeding.
