Phenothiazines are used to treat serious mental and emotional disorders, including
schizophrenia and other psychotic disorders
. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients.
What are some examples of phenothiazines?
Examples of phenothiazines include:
chlorpromazine (brand name: Thorazine)
, fluphenazine (Duraclon), mesoridazine (Serentil), perphenazine (Etrafon and Trilafon), prochlorperazine (Compazine), promazine (Robinul and Anectine), thioridazine (Mellaril), trifluoperazine (Stelazine) and triflupromazine (Robinul).
What class is phenothiazine?
Phenothiazines are a class of
first-generation heterocyclic anti-psychotic medications
, which display antagonistic activity towards dopamine receptors and recently have been shown to have potential anti-neoplastic properties.
Which antipsychotics are phenothiazine?
- prochlorperazine (Compazine, Compro, Procomp),
- chlorpromazine (Promapar, Thorazine),
- fluphenazine (Permitil, Prolixin),
- perphenazine,
- trifluoperazine (Stelazine),
- thioridazine (Mellaril), and.
- mesoridazine (no longer available in the United States).
What is a phenothiazine antiemetic?
Phenothiazine antiemetics are a
type of medicine that may be used to relieve nausea and vomiting
. They work by inhibiting dopamine, muscarinic and histamine (H1) receptors generally in the vomiting center and chemoreceptor trigger zone.
How do phenothiazines affect behavior?
The dopaminergic blocking properties of the phenothiazines and the butyrophenones may
alter sexual behavior
, presumably by depleting central monoamine neurotransmitters. Most cases of erectile dysfunction occur shortly after initiation of the drug, often within 24 hours.
What are the side effects of phenothiazines?
Constipation, trouble urinating, dryness of mouth, confusion, problems with memory, dizziness or fainting, drowsiness, trembling of the hands and fingers
, and problems with muscle movement, such as decreased or unusual movements, are especially likely to occur in elderly patients, who are usually more sensitive than …
What is the best known phenothiazine?
Among the most widely used phenothiazines are
chlorpromazine
(marketed under Thorazine and other trade names), thioridazine (Mellaril), and trifluoperazine (Stelazine).
Which phenothiazine has the least extrapyramidal effects?
Olanzapine has been associated with most frequently with weight gain, increased appetite, and somnolence.
Quetiapine
is the least likely to cause extrapyramidal side effects.
Is Xanax a phenothiazine?
Compazine is used to treat psychotic disorders such as schizophrenia. Compazine is also used to control severe nausea and vomiting. Xanax is also used to treat panic attacks. Compazine is
a phenothiazine anti-psychotic
and Xanax is a benzodiazepine.
Is chlorpromazine an antidepressant?
Chlorpromazine is a
psychiatric medication
that belongs to the class of drugs called phenothiazine antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.
Is Zofran a phenothiazine?
The brand name Compazine is discontinued in the U.S. Generic versions of prochlorperazine may still be available. Zofran and Compazine belong to different drug classes. Zofran is a selective 5-HT3 receptor antagonist and Compazine is
a phenothiazine anti-psychotic
.
Is phenothiazine a sedative?
Phenothiazines have been widely used for their
antiemetic, antipsychotic and sedative properties
for many years. The introduction of alternative agents for paediatric sedation has led to the re-evaluation of phenothiazines as paediatric sedatives.
What movement disorders can you see with phenothiazines?
Movement disorders (
acute dystonia, parkinsonism, akathisia, and tardive dyskinesia
) frequently are seen with phenothiazine use. Acute dystonic reactions (oculogyric crisis, torticollis, retrocollis, and opisthotonos) typically occur within 24 to 72 hours of phenothiazine use.
Are phenothiazines tranquilizer?
Phenothiazine Tranquilizers
The most commonly used phenothiazines in veterinary medicine are acepromazine, chlorpromazine, and promazine. In domestic animals, they are used as tranquilizers, preanesthetic agents, antiemetics, and for treatment of CNS agitation after specific drug overdoses (amphetamines, cocaine).
Are phenothiazines antihistamines?
An
antihistamine agent used to prevent and relieve allergic conditions
which cause pruritus and other allergic skin conditions, including urticaria. A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
