What Is The Most Effective Antidepressant?
What Is The Most Effective Antidepressant? The most effective antidepressant compared to placebo was the tricyclic antidepressant amitriptyline, which increased the chances of treatment response more than two-fold (odds ratio [OR] 2.13, 95% credible interval [CrI] 1.89 to 2.41). What is the drug of choice for depression? Antidepressants are a popular treatment choice for depression.